Multifunctional Mesoporous Silica Nanoparticles for Oral Drug Delivery
نویسندگان
چکیده
Nanotechnology has transformed engineering designs across a wide spectrum of materials and applications. Mesoporous Silica Nanoparticles (MSNs) are one the new fabrications nanostructures as medication delivery systems. MSNs have pore sizes varying from 2 to 50 nm, making them ideal for variety biological They offer unique characteristics such tunable surface area, well-defined properties, ability improve drug pharmacokinetic characteristics. Moreover, they potential reduce adverse effects by delivering precise dose medications specific spot rather than more frequent systemic delivery, which diffuses tissues organs. In addition, vast number pores allow incorporation transportation drugs various sites feasible platform orally administered drugs. Though oral route is most suitable convenient conventional systems associated with several limitations. Surpassing gastrointestinal barriers low bioavailability poorly soluble medicines pose major challenge in pharmaceutical industry. This review provides insights into role its mechanism an system.
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1Department of Chemistry, Nanosystems Initiative Munich (NIM) and Center for Nano Science (CeNS), University of Munich (LMU), Butenandtstr. 11 (E), 81377 Munich, Germany 2Department of Pharmacy, Pharmaceutical Biotechnology, Nanosystems Initiative Munich (NIM) and Center for Nano Science (CeNS), University of Munich (LMU), Butenandtstr. 5-13, 81377 Munich, Germany # authors contributed equally ...
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ژورنال
عنوان ژورنال: Coatings
سال: 2022
ISSN: ['2079-6412']
DOI: https://doi.org/10.3390/coatings12030358